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Preheat your oven to 375°F (190°C) and grease a 9×13-inch baking dish.
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In a large skillet, brown the ground beef over medium heat until fully cooked. Drain any excess fat.
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Cook the cheese tortellini according to the package instructions. Drain and set aside.
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In a large mixing bowl, combine the cooked ground beef, marinara sauce, garlic powder, onion powder, salt, and pepper.
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Add the cooked tortellini to the beef mixture and stir until well combined.
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Pour the mixture into the prepared baking dish and top with shredded mozzarella and Parmesan cheese.
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Cover the dish with foil and bake for 20 minutes. Then, remove the foil and bake for an additional 10 minutes, or until the cheese is bubbly and golden brown.